Beside the well‐established AD pathogenetic features, that is, Aβ peptides aggregation and tau protein hyperphosphorylation, an increasing body of evidence is highlighting the contribution of alterations of both the endolysosomal network and autophagic process in AD development (Cataldo et al., 1997; Jansen et al., 2019; Yu et al., 2005). This evidence concerns the gene MAPT and Alzheimer disease.