We report recent studies which describe how changes in endosomal genetics impact on functional events, such as the amyloidogenic and non‐amyloidogenic processing, degradative pathways, and the importance of receptors related to endocytic trafficking, including the 37/67 kDa laminin‐1 receptor ribosomal protein SA, and their implications for neurodegenerative diseases. Here, RPSA is linked to neurodegenerative disease.