The use of receptor inhibitors revealed the possibility to modulate APP maturation and intracellular localization in neuronal cells, as well as to restore the lost “correct” APP intracellular localization, mitochondrial network and Aβ levels in fibroblasts from familial AD‐affected patients (Bhattacharya, Izzo, et al., 2020; Bhattacharya, Limone, et al., 2020). Here, APP is linked to Alzheimer disease.