Studies demonstrating a decrease in Aβ production by impairing acidification of endolysosomal system (Schrader‐Fischer & Paganetti, 1996), together with alteration of APP endocytosis under low‐potassium conditions (Koo & Squazzo, 1994), reinforce the scenario prospecting endosomes as a hub in AD pathogenesis. This evidence concerns the gene APP and Alzheimer disease.