RAB5A and Alzheimer disease: Rab5 overactivation on endosomes in AD, derives mainly from the interaction between the high level of APP‐βCTF and APPL1 (adaptor protein containing pleckstin homology domain, phosphotyrosine binding domain, and leucine zipper motif) that is recruited to the Rab5 complex on endosomes (Kim et al., 2016).