Another AD‐risk gene is CD2AP which encodes for a protein involved in endocytosis and endosome's morphology (through interaction with Rab4) (Cormont et al., 2003; Gauthier et al., 2007), as well as in growth factor‐induced endocytosis (Kobayashi et al., 2004) and APP lysosomal trafficking (Furusawa et al., 2019). This evidence concerns the gene CD2AP and Alzheimer disease.