JPH3 and Huntington disease-like 2: These genes are PANK2, which encodes a mitochondrial protein whose mutations results in Panthothenate Kinase-Associated Neurodegeneration (PKAN) (44), and JPH3, which encodes junctophilin 3, an ER-to-PM tether whose mutations result in the so-called Huntington Disease Like 2 (HDL2) (45).