Most associations were found between IGHV status and protein dependence coefficients (Fig 3B): as previously described, U-CLL samples showed a higher dependence on BCR signaling components such as BTK, INPPL1, or MAPK/ERK pathway components (Fig 3B and 3C) [16,36]. The gene discussed is INPPL1; the disease is B-cell chronic lymphocytic leukemia.