ESCO2 and neoplasm: While this study has focused on ESCO2, SCC is a complex network of pro-cohesion factors and anti-cohesion factors (yeast genetics suggests over 350 genes involved) [58], in which the synergistic or antagonistic effects of combined mutations/polymorphisms in these genes can create varying degrees of SCC dysfunction amongst a population of individuals and potentially define variability of tumor penetrance between individuals.