The first patent is IT1426278 (Title-DWPI: Anti-human p53 antibody in kit used for detecting isoform of human p53 protein in sample, and diagnosing AD, is specifically binds to linear epitope of human p53, where the anti-human p53 antibody comprises ten amino acids) which was applied in 2014, with 3 citing patents and 22 patent family members (WO2016050630-A1, IT1426278-B, EP3201234-A1, CN107001453-A, JP2017534595-W, US2018057572-A1, HK1241896-A0, etc.). This evidence concerns the gene TP53 and Alzheimer disease.