The patent WO2004094460 (Title-DWPI: New purified brain-type natriuretic peptide (BNP) fragment for diagnosing cardiovascular diseases such as stroke, congestive heart failure, cardiac ischemia or hypertension) was applied in 2005, with 59 citing patents and 10 patent family members (WO2004094460-A2, US2005064511-A1, EP1616181-A2, JP2006527190-W, US7341838-B2, US2008160540-A1, EP1616181-B1, DE602004022527-E, WO2004094460-A3, EP1616181-A4) in DII. Here, NPPB is linked to myocardial ischemia.