HDAC3 and melanoma: Notably, the melanoma antigen MAGED1 [139], which also displays hyperacetylated sites upon HDAC3 deletion/inactivation, plays a major role in apoptosis and cell cycle arrest [140,141], which could provide a further link between HDAC3 function and the reduced viability of HDAC3 CI or HDAC3 KO clones.