▪Analysis of 48 apoptosis and 35 oxidative stress genes after plasma treatment▪BCL2A1 increased only in plasma‐treated TNBC lines▪Silencing BCL2A1 augmented plasma‐induced cytotoxicity in breast cancer cells▪BCL2A1 was described before to contribute to malignancy and chemoresistance. Here, BCL2A1 is linked to breast cancer.