▪Gas plasma suppressed, depending on treatment condition, BC cells proliferation by down‐regulation of ZNRD1 and its antisense long noncoding RNA ZNRD1‐AS1 expression▪Modified the methylation status of CpG sites▪Inhibited growth rate and colony formation in ZNRD1 and ZNRD‐AS1 transfected BC cells. Here, POLR1H is linked to breast cancer.