▪Mitochondria oxidation and metabolic activity decline in 2D BC cells and 3D BC spheroids▪DAMPs and ICD‐associated molecules (HSP70, HSP90, calreticulin, PD‐L1, MHC‐I, ATP, IFN‐α2, IFNγ, IL‐6) observed in treated cells. The gene discussed is HSP90AB1; the disease is breast cancer.