Activation of WNT signaling in osteoclasts, osteoblasts, and cancer cells resulted in their conversion to tumor-suppressive cells with secretomes enriched with Hsp90ab1, enolase 1 (Eno1), moesin (MSN), and ubiquitin C (Ubc), which acted as atypical tumor-suppressors [204–206]. The gene discussed is ENO1; the disease is cancer.