WNT activation by LRP5/ß-catenin overexpression in osteocytes generated tumor-suppressive secretomes, which successfully suppressed tumor growth and bone destruction by downregulating chemokines CXCL1 and CXCL5, upregulating tumor suppressors such as P53 and suppressing the expression of oncogenic genes such as MMP-9, Runx2, TGFβ, and Snail [201,202]. This evidence concerns the gene RUNX2 and neoplasm.