In bone metastasis of prostate cancer, novel tumor suppressive miRNAs, miR-582-3p, and miR-582-5p inhibit bone metastases through inactivation of NF-κB signaling [168,169], whereas miR-532-3p and miR-204-5p by suppressing TGF-ß signaling activity [170], suggesting a strong potential as therapeutic target. Here, NFKB1 is linked to Familial prostate cancer.