The precise definition of ANs is not agreed upon in the literature or latest edition of the WHO classification of central nervous system tumors, however there is a consensus that MIB-1 staining for Ki-67 antigen with values greater than 2–3%, with or without cellular atypia, have significant association with a worse prognosis [8, 10–12]. Here, MKI67 is linked to central nervous system neoplasm.