RPS19 and neoplasm: This Set 1 group of rpl33a of substitution mutations affect residues that (i) interact with eL6 (Tyr-44 and from Leu-102 to Ile107)) (Figs. S2-B and S1-B) and the 25S rRNA ES7 (Pro-104 and Asn-106) (Fig. S1-C) (ii) belong to the 22-residue motif conserved in the L35Ae family (Gly-69, Gly-76 and Gly-76, Gly-79), or (iii) were found mutated in patients with DBA (∆99–107) or in tumor entities (Gly-79).