Five Set 2 mutations, rpl33a-L7R, V35R, F43R, Y103R and A40-44 could perturb different contacts of eL33 with r-protein eL6 (Fig. S3 A-C), whereas ∆L29, the equivalent in yeast of the ∆L27 mutation in human rpL35A/eL33 identified in DBA probands (Farrar et al. 2008), could impair interaction with 25S rRNA domain II (Fig. S4-A). Here, RPL6 is linked to Diamond-Blackfan anemia.