INS and diabetes mellitus: From this point, different types of diabetes were considered, but the aetiological basis of the insulin-deficient disease type was not identified as autoimmune in origin until later, with Willy Gepts reporting evidence of immunological infiltrates in the pancreases of newly diagnosed children with diabetes in 1965 [8], which was reinforced by the identification of islet cell autoantibodies by Franco Bottazzo in 1974 [9].