CCL2 and cancer: One of the main mechanisms that cancer cells employ to increase the recruitment of TAMs to primary tumors and metastatic sites is the release of monocyte chemoattractant protein 1 (MCP‐1 or CCL2),[7] which attracts monocytes to the tumor microenvironment (TME) through the CCL2‐CCR2 cascade.[8] Once monocytes reach tumor sites, they differentiate into TAMs to support the expansion and intravasation of cancer cells.