Furthermore, TAMs are known to upregulate the expression of cysteine cathepsins,[9] which 1) facilitates further recruitment of monocytes from circulation to the TME,[10] and 2) protects tumors from the effect of some chemotherapeutic drugs.[9] Fluorescent probes including cell‐targeting peptide structures[11] or chemokine proteins[12] as well as cathepsin‐reactive activity‐based probes[13] have been used to image cancer models, yet there are no examples of cathepsin‐activatable chemokines as dual‐selective AND‐gate probes to target subsets of macrophages in tumors. The gene discussed is CTSS; the disease is cancer.