(A) MC38 tumor cells were implanted subcutaneously in WT and Piezo1-/- mice (n=10), IL-12 100 ng or anti-TGFβ1 mAb 200 ng per mouse in 50 μl volume or vehicle (PBS) was locally injected into tumor once a week and tumor size was measured every 5 days for 40 days. The gene discussed is TGFB1; the disease is neoplasm.