Recent studies have suggested that Piezo1 is involved in regulating many of diseases, including the infectious inflammation and cancer (Nguetse et al., 2020; Choi et al., 2019; Nonomura et al., 2018; Chang et al., 2019; Xie et al., 2022; Kuriyama et al., 2022; O’Callaghan et al., 2022; Liu et al., 2021). Here, PIEZO1 is linked to cancer.