Piezo1 exerts significant regulatory effects on many kinds of immune cell functions including macrophages, DCs, and T cells in inflammation and cancer (Solis et al., 2019; Geng et al., 2021; Aykut et al., 2020; Atcha et al., 2021; Chakraborty et al., 2021; Jairaman et al., 2021). The gene discussed is PIEZO1; the disease is cancer.