Piezo1-/- mice had more Foxp3+ Treg cells, fewer IFNγ+ TH1 cells, and normal numbers of TH2, TH17, CD8+T cell, and IFNγ+CD8+T cells in tumor tissue compared with WT control (Figure 1B, Figure 1—figure supplement 4A-B). The gene discussed is FOXP3; the disease is neoplasm.