Interestingly, a similar pattern of lower expression of many inflammatory markers occurred in both male WTfl/fl and male AdipoIRF4fl/fl mice after MDP treatment (Figure 3b), despite male AdipoIRF4fl/fl mice being refractory to NOD2‐mediated glucose changes during low‐level endotoxemia (Figure 1b) and during obesity (Figure 2b). Here, NOD2 is linked to obesity due to melanocortin 4 receptor deficiency.