37,38 Most NEK1 variants cause loss of function.37 Although, the exact mechanism underling NEK1 causing ALS is still unclear, an interaction between NEK1 and another ALS gene, chromosome 21 open reading frame 2 gene (C21orf2), has been reported as being important to ensure an efficient DNA damage repair response.39 In contrast, we demonstrated that loss of NEK6 may be beneficial for C9orf72 neurons or neurons exposed to DPRs. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.