Walkers et al., demonstrated that there is a significant accumulation of genome damage and induction of cellular senescence in C9orf72-models.42 Other studies also demonstrated increased DNA damage levels, which cause axonal degeneration or axonal transport defects in different ALS iPSC models.41,43 In general, genome damage-mediated cellular senescence is p53-mediated. Here, TP53 is linked to amyotrophic lateral sclerosis.