Accordingly, we found an augmented infiltration of CD8+ TILs in FAT/FRY subtype ESCC, and tumors with FRY mutant alone also had more CD8+ TILs compared with WT tumors, suggesting that FAT/FRY tumors still had active antitumor immunity (Figure 6, E and F). Here, CD8A is linked to esophageal squamous cell carcinoma.