In our discovery cohort, we observed that the core members (FAT1 and LATS2) of Hippo pathway were significantly underexpressed in the FAT/FRY ESCC subtype, whereas the transcriptional targets of YAP1 (CTGF and CYR61) were significantly increased, verifying the inactivation of Hippo pathway in this subgroup (Figure 6B). The gene discussed is FAT1; the disease is esophageal squamous cell carcinoma.