To assess whether ROBO3 maintained p-STAT3 activity via AXL, we silenced ROBO3 in BL cell lines, which caused a marked reduction in AXL, p-STAT3, and WNT10A in both BL cell lines following ROBO3 silencing (Supplemental Figure 5, B and C). This evidence concerns the gene ROBO3 and Burkitt lymphoma.