NOTCH3 and chronic obstructive pulmonary disease: With a relatively loose threshold (p < .2), the genes Dhx16, Upf2, Denr, Notch3, Dyrk2, Sec61a1, Hmmr, and Noa1 were reversed in at least three treatment protocols and most of these genes were reported to be related to COPD or lung cancer [37–41].