The MOK protein is encoded by the receptor for advanced glycation endproducts1 (RAGE1) gene, which has been considered as a tumour-associated antigen for its wide expression in various tumours, including melanoma [71], renal cell carcinoma [72], head and neck cancer [73], mesothelioma [74], hepatocellular carcinoma [75] and acute myeloid leukaemia [76], but silenced in normal tissues with the exception of the retina [71]. This evidence concerns the gene MOK and hereditary clear cell renal cell carcinoma.