IL2RA and graft versus host disease: Most commonly, GVHD is studied by the transplantation of hPBMCs into immunodeficient mice encoding targeted mutations in the Il2rg gene [70], which results in the complete absence of the IL-2R γ-chain (Il2rgtm1Wjl) or a truncated IL-2R γ-chain lacking the intracytoplasmic domain (Il2rgtm1Sug), both of which prevent murine NK cell development [71].