In the sub-analysis of hypoxic subvolumes of AC patients (Fig. 4B), the percentage of Ki67, p53, CXCR4 and PD1 positive tumor cells were significantly higher within hypoxic regions compared to the normoxic regions regardless of the previous treatment, except for PD1 in the NRCHT + R cohort. This evidence concerns the gene MKI67 and neoplasm.