SLC40A1 and diabetes mellitus: Furthermore, through animal experiments and using tubular injury cell models induced by high glucose and palmitic acid concentrations, it was confirmed that dapagliflozin and SLC40A1 could bind with each other; this may induce conformational changes in SLC40A1, which subsequently causes a reduction in ubiquitination degradation and consequently ameliorates tubular ferroptosis in diabetes (Figure 6(e)).