For example, ischemia/reperfusion injury induced Tau phosphorylation through cyclin-dependent kinase 5 (CDK5) [33]; sleep disturbances-associated Tau phosphorylation was mediated via p38 mitogen-activated protein kinase (p38MAPK) [34]; virus infection enhanced Tau phosphorylation by double-stranded RNA-dependent protein kinase [35]; sepsis triggered Tau phosphorylation through GSK-3β [36]; and metal dysregulation activated rapamycin/ribosomal S6 protein kinase and thus caused Tau phosphorylation [37]. The gene discussed is MAPT; the disease is viral infectious disease.