Among them, M2 macrophage infiltration is clearly related, and M2-like tumor-associated macrophages play an important role in the immune microenvironment of gliomas [27], and the high expression of RPL4P4 promotes the inhibitory phenotype of macrophages, thereby promoting tumor progression, which indicates that RPL4P4 may serve as a potential biomarker. The gene discussed is RPL4P4; the disease is glioma.