Resveratrol showed antioxidant activity and anti-Aβ formation features both in vivo, in Tg2576 mice, and in vitro through different molecular mechanisms, including inhibition of β-amyloid-induced neuronal apoptosis via regulation of the silent information regulator 1 (SIRT1)-Rho-associated kinase 1 (ROCK1) signaling pathway in PC12 cells and by promoting non-amyloidogenic processing of APP, and thus mitigating Aβ neuropathology in AD (Wang et al., 2006; Ladiwala et al., 2010; Feng et al., 2013). This evidence concerns the gene APP and Alzheimer disease.