At histopathological level, the main AD hallmarks are: (i) extracellular β-amyloid (Aβ) deposits, and (ii) intracellular neurofibrillary tangles (NFTs), containing bundles of paired helical filaments of the microtubule-associated hyperphosphorylated protein tau (Grundke-Iqbal et al., 1986; Nukina and Ihara, 1986). This evidence concerns the gene MAPT and Alzheimer disease.