The most common action mechanisms of plant-derived agents against AD, ranges from anti-amyloidogenic activity as well as inhibition of tau hyperphosphorylation and tangle clearance, to the anti-inflammatory potential within the neuroglia and protection against free radical-induced neurodegeneration, thereby exhibiting important neuroprotective effects by enhancing the memory and learning process that normally regress in patients (Baum et al., 2008; Ahmad et al., 2016; Ali et al., 2017; Ayaz et al., 2017a,b). Here, MAPT is linked to Alzheimer disease.