PSEN1 and Alzheimer disease: Yet another interesting preclinical study was based on the injection of curcumin-conjugated nanoliposomes, with curcumin exposed at their surface, into the hippocampus and the neocortex of the double transgenic APP/PS1 mouse model of AD; the authors exploited the behavior of curcumin that, being a fluorescent molecule and having high affinity for the Aβ peptide, was able to specifically label Aβ deposits in vivo both in AD mouse brains and human post-mortem AD brains as well as to downregulate the secretion of the amyloid peptide in vitro.