To investigate the specific mechanism, MA can improve the cognitive function by regulating abnormal expressions of Aβ and Tau proteins in AD-related brain regions (Jiang et al., 2019; Sun et al., 2021), inhibiting the central inflammatory response (Ding et al., 2017), regulating cerebral blood flow (Ding et al., 2019b), modulating energy metabolism (Liu et al., 2017), and improving neuronal synaptic plasticity (Xiao et al., 2018), which exhibits the multitarget effect of MA. The gene discussed is MAPT; the disease is Alzheimer disease.