Li et al. (2016) showed that folic acid upregulated DNA methylation in N2a-APP cells and AD transgenic mice and analyzed the role of folic acid in JAK-STAT and LTD signaling pathways and its value in AD treatment. Therefore, increasing methylation levels and activities may represent a potential therapeutic strategy for ameliorating AD (Wang et al., 2013; Li et al., 2016). This evidence concerns the gene APP and Alzheimer disease.