It also increased Rock2 activity and hyperphosphorylation of Add1 at Ser726, leading to dendritic abnormalities and memory impairment and blocking the phosphorylation of Add1 at Ser726, overexpression of miR-135a-5p, or silencing Rock2 effectively rescued synaptic disorders and memory impairment in AD mice (Zheng et al., 2021). Here, ADD1 is linked to Alzheimer disease.