LncRNA-51A is known to modulate the splicing of sortilin-related receptor 1, an essential gene for traffic and recycling of the β-amyloid precursor, reducing the synthesis of sortilin-related receptor 1 variant A. In bioinformatics/reannotation studies supporting the interplay between lncRNAs and AD, it was predicted that lncRNA sequences were associated with the genes encoding APP, ApoE, PS-1, and PS-2 (Holden et al., 2013). Here, PSEN1 is linked to Alzheimer disease.