NR4A2 missense variants considered to cause NDD occurred in DBD and LBD regions, while others occurring in N-terminal domain (c.289A > G, c.308A > G and c.374C > G) tend to be associated with susceptibility of Parkinson’s disease or schizophrenia, in which a different mechanism might play a role. This evidence concerns the gene NR4A2 and Parkinson disease.