NR4A2 and Neurodevelopmental delay: The results of our study provided more evidence for the role of NR4A2 haploinsufficiency in NDD and updated the mutation spectrum of NR4A2. Meanwhile, we briefly reviewed the NR4A2 variants and clinical manifestations and found that loss-of-function variants and missense variants occurring in the key domains of NR4A2 were generally intolerant.