A previous study showed that increasing the phosphorylation of Akt in hippocampal neurons by activation of BDNF/TrkB signaling would upregulate NMDA receptors and promote synaptic plasticity (Nakai et al., 2014), and cognitive decline in different models accompanied by decreasing the level of BDNF/TrkB signaling (Mercerón-Martínez et al., 2021). The gene discussed is AKT1; the disease is Mental deterioration.