To determine if PD-L1 would be upregulated by non-TA-specific T cells, we selected three of the eight original MDS patients (Pts 3, 11, 15) and stimulated their T cells with a pool of viral peptides (CEF: cytomegalovirus, Epstein Barr virus, and influenza virus) prior to coculture with autologous MDS cells. This evidence concerns the gene CD274 and myelodysplastic syndrome.