(73) enrolled B-ALL-negative patients for BCR-ABL1 (Ph− B-ALL) population, including children, adolescents, and adults; the CDKN2A/B/RB1 deletion was reported as the negative prognostic factor (HR 2.12, P = 0.048) regardless of age. This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.