ABCB1 and ABCG2 transporters have established roles in conferring multidrug resistance by lowering intracellular drug accumulation resulting from extrusion of drugs from the tumor cells. Herein, resistance fold (RF) was used to assess if there was any degree of change in the resistance to ITH-6 due to the presence of ABCB1or ABCG2 (41). This evidence concerns the gene ABCG2 and neoplasm.