MTOR and cancer: Aside from the evaluation of dECM sources, Ayuso et al. (79) compared 3 culture models, namely, (I) 2D monolayer cocultures with primary cancer-associated fibroblasts and H&N cancer cell lines (UM-SCC-1 and UM-SCC-47), (II) 3D collagen hydrogel scaffolds seeded with H&N cancer cells, and (III) 3D H&N cancer cell spheroids of their responses to cetuximab and an mTOR inhibitor.