To reflect this environment, in one of the very early in vitro studies with H&N squamous cell carcinoma cultures collected from larynx, retromolar trigone, cervical lymph node, and the floor of mouth, the inhibition of the EGFR was assessed by incorporating two anti-EGFR monoclonal antibodies (MAbs 425 and 528) based on in vitro models (12). This evidence concerns the gene EGFR and squamous cell carcinoma.