PLK1 and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, the greatest upregulation of the apoptotic activator BAX was observed in K562R cells following danusertib and volasertib treatments, indicating that both Aurora kinase A and PLK1 play a key role in sustaining resistant CML cells, since their inhibition is a stressful condition that triggers apoptosis.