Furthermore, the percentages of CD4+ and CD8+ T cells were induced by the combination treatment in tumor tissues (Figures 3B, S2C, D, p< 0.05), and the combined therapy increased the proportion of CD4+ T cells in the peripheral blood of mice, without affecting CD8+ T cells (Figures 3C, S2E, F, p< 0.05). The gene discussed is CD4; the disease is neoplasm.