CECs expressing Bcl-2 in the patient blood samples might be originating from tumor microvasculature and their binding to tumor cells induces a marked increase in Src and FAK activation in tumor cells, with anchorage independent survival (222), inhibition of both apoptosis, through regulating Bim, and anoikis, through regulating BAD (223, 224). This evidence concerns the gene BAD and neoplasm.