Progression into the cell cycle, CD40L-NF-kB–mediated Bcl-xL upregulation, downmodulation in the expression of the proapoptotic Bim, Bax, and Bak proteins (186) and ultimately a decrease in mitochondrial priming and drug resistance have been recently confirmed in Mantle cell lymphoma (MCL) by using an ex vivo model (187). Here, CD40LG is linked to mantle cell lymphoma.