Of note, a CTCcl+ gene signature consisting of 54 upregulated genes has been identified, significantly associated with poor relapse-free survival (RFS) in 360 patients with basal-like BC advancements (199), confirming Bcl2 expression as a poor prognostic factor in triple negative breast cancer (TNBC) patients, especially in the absence of adjuvant therapy (204). Here, BCL2 is linked to breast cancer.