Progression into the cell cycle, CD40L-NF-kB–mediated Bcl-xL upregulation, downmodulation in the expression of the proapoptotic Bim, Bax, and Bak proteins (186) and ultimately a decrease in mitochondrial priming and drug resistance have been recently confirmed in Mantle cell lymphoma (MCL) by using an ex vivo model (187). The gene discussed is BAK1; the disease is mantle cell lymphoma.