The most significant factors predisposing to the development of ovarian cancer include menopause (OR: 10.64; 95% CI 4.17-27.1), TUFT1 protein overexpression (OR: 9.76; 95% CI 0.21-458.99), UBA2 protein overexpression (OR: 5.69; 95% CI 2.95-10.97), and GLO1 protein overexpression (OR: 5.68; 95% CI 0.18-180.09). The gene discussed is TUFT1; the disease is ovarian carcinoma.