In the luciferase reporter assay of H1299 (p53-null) cells (lung cancer cell line), DDX5/DDX17 interacted with p53 and acted as coactivators of p53, promoting the transcription of p53-targeted genes, but the co-activation ability of DDX17 is weaker than that of DDX5 (69). The gene discussed is TP53; the disease is lung cancer.