DDX5 and glioblastoma: In addition, Y593-phosphorylated DDX5 promotes the nuclear translocation of β-catenin by blocking the β-catenin phosphorylation induced by GSK-3β and replacing Axin in the β-catenin complex, then activating β-catenin target genes cyclin D1 and c-Myc transcription and stimulating cell proliferation (115) In glioblastoma, dual Y593-/Y595- phosphorylated DDX5 inhibits cell apoptosis by inhibiting XAF1 expression.