Phosphorylated DDX5 blocks the phosphorylation of β-catenin by GSK-3β and displaces Axin in the β-catenin complex to promote the nuclear translocation of β-catenin (115); moreover, DDX5 acts as a coactivator of β-catenin to promote the transcription of β-catenin target genes (such as c-Jun, c-Myc, RelA, and cyclin D1), which directly promote NSCLC and colon cancer cells proliferation (27, 123). This evidence concerns the gene JUN and malignant colon neoplasm.