E2F1 and thyroid cancer: In human thyroid cancer cells, SLC26A4-AS1 silencing enhances the interaction between DDX5 and the transcription factor E2F1; then, the DDX5-E2F1 complex binds to the MRN gene promoter and thus stimulates the MRN/ATM-dependent DNA DSB signaling cascade and thyroid cancer metastasis (97).