DDX5 and breast carcinoma: Knockdown experiments with short interfering RNA (siRNA) in MCF-2 cells (breast cancer cell line) have shown that DDX5 plays an important role in inducing the transcriptional activity of p53 in response to DNA damage but that knocking down DDX17 expression has no significant effect (69), suggesting that the effect on the p53 DNA damage response is specific to DDX5.