DDX5 and Familial prostate cancer: For instance, simvastatin inhibits renal cell carcinoma cell proliferation by reducing DDX5 expression (153); resveratrol inhibits prostate cancer growth by promoting DDX5 degradation (136); the tumor suppressor DRD2 inhibits breast cancer by downregulating DDX5 expression (154); 2F5, the DDX5-targeting fully human monoclonal autoantibody, selectively inhibited the proliferation of acute promyelocytic leukemia cells (144).