The lncRNA PRADX binds to the enhancer of zeste homolog 2 (EZH2) protein, recruits the PRC2/DDX5 complex, increases the abundance of H3K27me3 on the UBXN1 promoter, inhibits the expression of UBXN1, then promotes the activity of NF-κB, thus promoting the development of glioblastoma and colon adenocarcinoma (106). The gene discussed is DDX5; the disease is colon adenocarcinoma.