In addition to interacting with p53, Wnt/β-catenin, Notch, ER, AR, and NF-κB, DDX5 or DDX17 engage in crosstalk with mTOR (136, 137), Smad3 (138), STAT3 (77), Akt (139), c-Myc (140), TGF-β1 (141), etc. DDX5/DDX17 interact with an overwhelming number of key tumor factors, and therefore, the importance of DDX5/DDX17 cannot be overemphasized. The gene discussed is TP53; the disease is neoplasm.