Although MMRi62 induces lysosomal degradation of ferritin heavy chain 1 (FTH1) and triggers ferroptosis in pancreatic cancer cells (46), FTH1 degradation is not involved in MMRi62-induced apoptosis in leukemia cells since MMRi67 induced the same level of FTH1 degradation as MMRi62 but without incurring apoptosis (Lama et al., unpublished data). Here, FTH1 is linked to familial pancreatic carcinoma.