In order to further investigate the functions of LIF in ccRCC, CancerSEA was used to determine whether LIF was related to the carcinogenic process in ccRCC, and it was found that the functional phenotype of LIF was positively related to angiogenesis, differentiation, quiescence, metastasis, inflammation, and cell cycle (Figure 4A). Here, LIF is linked to nonpapillary renal cell carcinoma.