AKT1 and neoplasm: A large amount of data indicate that the anti-radiosensitivity in EC refers to PI3K/PTEN/AKT/mTOR signaling pathway, MAPK signaling pathway, and NF-kB signaling pathway; each of them is directly or indirectly involved in tumor radio-resistance and GLUT1-induced malignant processes that include proliferation, angiogenesis, and EMT in EC (124, 125).