The KEGG pathway enrichment study suggested that Kochiae Fructus anti-COVID-19 key targets may be implicated in the AGE-RAGE signaling pathway in diabetic complications, the VEGF signaling pathway, cancer pathways, neurodegeneration-multiple diseases pathways, inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Fc epsilon RI signaling pathway, Sphingolipid signaling pathway, TNF signaling pathway, HIF-1 signaling pathway, etc. These pathways may contribute substantially to the underlying mechanisms of Kochiae Fructus in alleviating COVID-19. The gene discussed is TNF; the disease is COVID-19.