gE has also been used in the study of recombinant vaccines, and since gE is an essential neurovirulence factor in animal models, its specific antibodies are readily detected in organisms with varicella, and T cell-mediated immunity against gE has been demonstrated (CMI) epitope, based on which the adjuvanted recombinant glycoprotein E herpes zoster vaccine developed is superior to the traditional HZ live attenuated vaccine (Levin and Weinberg, 2020). The gene discussed is ART4; the disease is herpes zoster.