Lactobacillus can not only downregulate the Wnt/β-catenin pathway (Ghanavati et al., 2020), but also upregulate TNF-related apoptosis-inducing ligand, downregulate the transcription expression of cyclin D1 and BIRC5a, reduce the proliferation of CRC cells, and induce apoptosis of CRC cells (Tiptiri-Kourpeti et al., 2016). The gene discussed is TNFSF10; the disease is colorectal carcinoma.