A sulfated polysaccharide constructed by sulfation of a glucan from the fruiting bodies of P. ribi, using chlorosulfonic acid protocol, exerted anti-cancer activity, which is the anti-angiogenic activity by intervention of proliferation, migration, and formation of vascular endothelial growth factor (VEGF) in EA.hy926, with the mechanism as downregulating the protein expression of VEGF and VEGF receptor-1 and restricting the phosphorylation of VEGF receptor-2, protein kinase B, and extracellular signal-regulated kinase (Liu et al., 2018). Here, VEGFA is linked to cancer.