MAPT and Cognitive impairment: To date, cognitive impairments, including memory, executive functioning, visuo-construction, language, and behavioral changes have been associated with tau pathology or MAPT mutation (Hu et al., 2007; Grossman et al., 2008; Mendez et al., 2013; Kamath et al., 2019; Poos et al., 2020; Benussi et al., 2021), while social cognition impairments were found in patients with C9orf72 (Russell et al., 2020; Franklin et al., 2021).