To assess whether knockdowns are similarly protective for target IDPs implicated by our SVM and NN algorithms, we quantified aggregate formation and progeny production after RNAi-mediated knockdown of C. elegans orthologs of six representative IDP genes with ≥ 40% disorder, enriched in both AD and PD aggregates (DHX9, PLEC, FABPH, TUBB4, GFAP, and MPPA). Here, TUBB4A is linked to Alzheimer disease.