In conclusion, it was found that anti-MDA5 antibody positivity is more common in patients with DM and that anti-MDA5 antibody positivity is more likely to be combined with interstitial pneumonia and poorer survival than anti-MDA5 antibody negative patients, with differences in ESR, Ferritin, and CK levels between the positive and negative groups. The gene discussed is IFIH1; the disease is dermatomyositis.