IFIH1 and interstitial lung disease: However, Mimori et al. found that effective immunosuppressive combination therapy using high-dose glucocorticoids, calcium-modulated neurophosphatase inhibitors, and cyclophosphamide should be considered as induction therapy for acutely progressive ILD, which is poorly effective and has a poor prognosis for patients with anti-MDA5 antibody-positive CADM who do not develop ILD.