In this study, it was initially discovered that miR-183-5p was silenced in LPS-stimulated sepsis mice, while augmented miR-183-5p reduced AST, ALT, BUN, and creatinine in serum of sepsis mice, the content of inflammatory factors, and the percentage of CD39+ Tregs, and tissue damage was ameliorated and the apoptosis index declined. Here, GPT is linked to Sepsis.