A previous study indicated that NPs camouflaged with purified leukocyte (human T-cell and murine macrophage) membranes presented cell-like behaviour in the blood circulation in the orthotopic 4T1 tumor models, which could molecularly interact with the surface of the cell through triggering and activating the clustering of intercellular adhesion molecule one on endothelial cells, increasing the targeting properties, promoting firm adhesion to the tumor vasculature, resulting in an increase in intracellular calcium and ROS concentrations, resulting in an independent activation of PKCα. Here, PRKCA is linked to neoplasm.