PKCα increases lead to the phosphorylation of vascular endothelial-cadherin (VE-cadherin, also known as cadherin-5 and CD144) that resulting in the disassembly of VE-cadherin and protein displacement, leading to enlarged gaps between endothelial cells and an increase in tumor vascular permeability (Palomba et al., 2016). This evidence concerns the gene CDH5 and neoplasm.